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Moskowitz, Ivan

One or more keywords matched the following properties of Moskowitz, Ivan

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overview	The Moskowitz laboratory is devoted to the genetic, genomic and molecular study of gene regulatory networks. A single overarching theme governs work in the Moskowitz laboratory: that understanding essential gene regulatory networks will unveil the molecular logic governing biological processes, and that understanding network disruption will inform the molecular basis underlying disease. We have recently pioneered approaches to identify non-coding RNAs as markers and modulators of enhancer function (Yang and Nadadur et al, 2017). The Moskowitz laboratory has focused on two areas of cardiac biology: (1) cardiac conduction with respect to cardiac arrhythmias and (2) cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we investigate the genetic, genomic and developmental landscape of cardiac morphogenesis. We have identified an essential role for Hedgehog signaling in the cardiac development and congenital heart disease and contributed to a paradigm shift in the understanding of cardiac septation (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in maintaining cardiac progenitor status and preventing premature differentiation (Rowton et al., 2018). In cardiac rhythm, we investigate the molecular mechanisms underlying the genetic basis of cardiac arrhythmias. We have defined the first molecular networks and linking GWAS loci in cardiac conduction (Arnolds et al, 2012), the first molecular network in Atrial Fibrillation, the most common arrhythmia world-wide (Nadadur et al., 2016) and the functional genomic mechanisms underlying genetic associations (Van den Boogaard et al., 2014).

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overview

The Moskowitz laboratory is devoted to the genetic, genomic and molecular study of gene regulatory networks. A single overarching theme governs work in the Moskowitz laboratory: that understanding essential gene regulatory networks will unveil the molecular logic governing biological processes, and that understanding network disruption will inform the molecular basis underlying disease. We have recently pioneered approaches to identify non-coding RNAs as markers and modulators of enhancer function (Yang and Nadadur et al, 2017). The Moskowitz laboratory has focused on two areas of cardiac biology: (1) cardiac conduction with respect to cardiac arrhythmias and (2) cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we investigate the genetic, genomic and developmental landscape of cardiac morphogenesis. We have identified an essential role for Hedgehog signaling in the cardiac development and congenital heart disease and contributed to a paradigm shift in the understanding of cardiac septation (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in maintaining cardiac progenitor status and preventing premature differentiation (Rowton et al., 2018). In cardiac rhythm, we investigate the molecular mechanisms underlying the genetic basis of cardiac arrhythmias. We have defined the first molecular networks and linking GWAS loci in cardiac conduction (Arnolds et al, 2012), the first molecular network in Atrial Fibrillation, the most common arrhythmia world-wide (Nadadur et al., 2016) and the functional genomic mechanisms underlying genetic associations (Van den Boogaard et al., 2014).

One or more keywords matched the following items that are connected to Moskowitz, Ivan

Item Type	Name
Concept	Actins
Concept	Action Potentials
Concept	Age Factors
Concept	Aortic Coarctation
Concept	Aortic Valve Stenosis
Concept	Arteries
Concept	Arrhythmias, Cardiac
Concept	Alleles
Concept	Cardiomyopathy, Hypertrophic
Concept	Animals, Newborn
Concept	Anal Canal
Concept	Cleft Lip
Concept	Base Sequence
Concept	Cations, Divalent
Concept	Cell Nucleus
Concept	Atrial Fibrillation
Concept	Chimera
Concept	Blastomeres
Concept	Biopsy
Concept	Bundle of His
Concept	Embryonic Induction
Concept	Bradycardia
Concept	Chromosomes, Human, Pair 1
Concept	Cardiomyopathy, Dilated
Concept	Chromosome Deletion
Concept	Cleft Palate
Concept	Coronary Artery Disease
Concept	Cysteine Endopeptidases
Concept	DNA, Bacterial
Concept	Down Syndrome
Concept	Cell Fusion
Concept	Echocardiography
Concept	Ductus Arteriosus, Patent
Concept	Cardiomegaly
Concept	Lac Operon
Concept	Electrophysiology
Concept	Cilia
Concept	DNA, Superhelical
Concept	Electrocardiography
Concept	Glycogen Storage Disease
Concept	Genes, Lethal
Concept	Fibroblast Growth Factors
Concept	Genetic Complementation Test
Concept	Heart Diseases
Concept	Heart Failure
Concept	Heart Septal Defects, Atrial
Concept	Embryo, Mammalian
Concept	Escherichia coli
Concept	Fluorescent Antibody Technique
Concept	Microfilament Proteins
Concept	Molecular Sequence Data
Concept	Pre-Excitation Syndromes
Concept	Procainamide
Concept	Tetralogy of Fallot
Concept	Poliomyelitis
Concept	Heart Defects, Congenital
Concept	Heart Septal Defects, Ventricular
Concept	Repressor Proteins
Concept	Risk Factors
Concept	Wolff-Parkinson-White Syndrome
Concept	Cohort Studies
Concept	Sarcomeres
Concept	Sodium
Concept	Spine
Concept	Transcription, Genetic
Concept	Truncus Arteriosus
Concept	Trisomy
Concept	Caenorhabditis elegans
Concept	Sodium Channels
Concept	Trans-Activators
Concept	Chromosomes, Artificial, Bacterial
Concept	Ventricular Fibrillation
Concept	Transforming Growth Factor beta
Concept	Vacuolar Proton-Translocating ATPases
Concept	Antigens, CD
Concept	Mortality
Concept	Gene Expression
Concept	Chromosomes, Mammalian
Concept	Connexins
Concept	Genes, Reporter
Concept	Cardiomyopathies
Concept	Myocarditis
Concept	Hypertrophy, Left Ventricular
Concept	Connexin 43
Concept	Cell Proliferation
Concept	Ventricular Dysfunction
Concept	Disease Progression
Concept	Basic-Leucine Zipper Transcription Factors
Concept	Transgenes
Concept	Chemokines, CC
Concept	Cardiomyopathy, Hypertrophic, Familial
Concept	Myosin Heavy Chains
Concept	In Situ Hybridization, Fluorescence
Concept	Fatal Outcome
Concept	Single-Cell Analysis
Concept	Peripheral Blood Stem Cell Transplantation
Concept	Chromatin Assembly and Disassembly
Concept	Smad4 Protein
Concept	Genomic Imprinting
Concept	Response Elements
Concept	Bone Morphogenetic Proteins
Concept	Small Ubiquitin-Related Modifier Proteins
Concept	Platelet Count
Concept	SUMO-1 Protein
Concept	Promoter Regions, Genetic
Concept	Hedgehog Proteins
Concept	Sarcoplasmic Reticulum
Concept	Brugada Syndrome
Concept	HEK293 Cells
Concept	E2F3 Transcription Factor
Concept	GATA4 Transcription Factor
Concept	GATA6 Transcription Factor
Concept	Wnt2 Protein
Concept	Kruppel-Like Transcription Factors
Concept	Adaptor Proteins, Signal Transducing
Concept	Insulin-Secreting Cells
Concept	Regulatory Elements, Transcriptional
Concept	Chemokine CCL4
Concept	Zebrafish
Concept	Fibroblast Growth Factor 4
Concept	Fibroblast Growth Factor 8
Concept	Heart Transplantation
Concept	Axonemal Dyneins
Concept	Cyclosporine
Concept	Mice, 129 Strain
Concept	Death, Sudden, Cardiac
Concept	Ventricular Outflow Obstruction
Concept	Genes, Helminth
Concept	Survival Rate
Concept	DNA Methylation
Concept	Troponin T
Concept	Stroke
Concept	T-Box Domain Proteins
Concept	Gene Silencing
Concept	Homeodomain Proteins
Concept	Cardiac Myosins
Concept	Ventricular Dysfunction, Left
Concept	Cell Lineage
Concept	Macrophage Inflammatory Proteins
Concept	Electrophysiologic Techniques, Cardiac
Concept	Transcriptome
Concept	Genome-Wide Association Study
Concept	Haploinsufficiency
Concept	Forkhead Transcription Factors
Concept	Atrial Septum
Concept	Calcium
Concept	Cell Line
Concept	Cells, Cultured
Concept	Brain Ischemia
Concept	Chromatin
Concept	Disease Models, Animal
Concept	Endothelium
Concept	Enhancer Elements, Genetic
Concept	Epidermis
Concept	Genetic Testing
Concept	Heart Septal Defects
Concept	Heart Valve Diseases
Concept	Hydrocephalus
Concept	Intercellular Junctions
Concept	Staining and Labeling
Concept	Translocation, Genetic
Concept	Regulon
Concept	Computational Biology
Concept	Genetic Predisposition to Disease
Concept	Genomics
Concept	Potassium Channels, Voltage-Gated
Concept	Sarcoplasmic Reticulum Calcium-Transporting ATPases
Concept	Genetic Loci
Concept	Cytoplasmic Dyneins
Academic Article	Comparison of two murine models of familial hypertrophic cardiomyopathy.
Academic Article	Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene.
Academic Article	Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.
Academic Article	The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.
Academic Article	Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome.
Academic Article	Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex.
Academic Article	A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
Academic Article	Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.
Academic Article	Characterization of sinoatrial node in four conduction system marker mice.
Academic Article	Complex genomic rearrangement in CCS-LacZ transgenic mice.
Academic Article	The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.
Academic Article	A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.
Academic Article	Genome-wide identification of mouse congenital heart disease loci.
Academic Article	A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.
Academic Article	Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.
Academic Article	Sarcomere mutations in cardiomyopathy with left ventricular hypertrabeculation.
Academic Article	TBX5 drives Scn5a expression to regulate cardiac conduction system function.
Academic Article	E2F3 plays an essential role in cardiac development and function.
Academic Article	Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]
Academic Article	Complex interactions between genes controlling trafficking in primary cilia.
Academic Article	Defective sumoylation pathway directs congenital heart disease.
Academic Article	Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease.
Academic Article	Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.
Academic Article	Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy.
Academic Article	sonic hedgehog is required in pulmonary endoderm for atrial septation.
Academic Article	DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.
Academic Article	Inducible recombination in the cardiac conduction system of minK: CreERT² BAC transgenic mice.
Academic Article	The emerging genetic landscape underlying cardiac conduction system function.
Academic Article	Giant cell myocarditis in a 12-year-old girl with common variable immunodeficiency.
Academic Article	Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Academic Article	Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.
Academic Article	Low-dose cyclosporin A therapy in children with refractory immune thrombocytopenic purpura.
Academic Article	Tetralogy of Fallot with congenital aortic valvar stenosis: the tetralogy-truncus interrelationship.
Academic Article	Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.
Academic Article	Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
Academic Article	MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.
Academic Article	Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.
Academic Article	A common genetic variant within SCN10A modulates cardiac SCN5A expression.
Academic Article	The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model.
Academic Article	Many ways to break a heart.
Academic Article	The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.
Academic Article	De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.
Academic Article	Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.
Academic Article	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.
Academic Article	TBX5: A Key Regulator of Heart Development.
Academic Article	Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation.
Academic Article	Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation.
Academic Article	Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription.
Academic Article	Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.
Academic Article	A promoter interaction map for cardiovascular disease genetics.
Academic Article	Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.
Academic Article	A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human.
Academic Article	Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.
Academic Article	Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.
Academic Article	A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.
Academic Article	Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development.
Academic Article	Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis.
Academic Article	Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.
Academic Article	Chromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq.
Academic Article	Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria.
Academic Article	Transcriptional Patterning of the Ventricular Cardiac Conduction System.
Academic Article	ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.
Academic Article	Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.
Academic Article	Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation.
Academic Article	Chamber-specific transcriptional responses in atrial fibrillation.
Academic Article	Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.
Academic Article	Control of cardiomyocyte differentiation timing by intercellular signaling pathways.
Academic Article	Author Correction: Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
Academic Article	Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
Academic Article	Identification of direct transcriptional targets of NFATC2 that promote ß cell proliferation.
Academic Article	Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.
Academic Article	Differential Etv2 threshold requirement for endothelial and erythropoietic development.
Academic Article	Detecting critical transition signals from single-cell transcriptomes to infer lineage-determining transcription factors.
Academic Article	Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.
Academic Article	Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.
Academic Article	Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.
Concept	N-Myc Proto-Oncogene Protein
Concept	Zinc Finger Protein GLI1
Concept	Homeobox Protein Nkx-2.5
Concept	Zinc Finger Protein Gli3
Concept	NAV1.5 Voltage-Gated Sodium Channel
Concept	NAV1.8 Voltage-Gated Sodium Channel
Concept	Filamins
Grant	Genetic and Molecular Analysis of Congenital Heart Disease
Grant	Gene Expression Networks for Human Cardiac Differentiation in Down Syndrome
Grant	Etiology of Congenital Heart Disease in Down Syndrome
Academic Article	Tbx5 maintains atrial identity by regulating an atrial enhancer network.
Academic Article	ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.
Academic Article	Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation.
Academic Article	The cGAS-STING pathway is dispensable in a mouse model of LMNA-cardiomyopathy despite nuclear envelope rupture.
Academic Article	An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract.
Academic Article	A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
Academic Article	Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network.

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